St. - Billerica, MA 01821
Headquartered in Billerica, MA, Pion Inc. supports the drug development
industry with a suite of innovative instrumentation, assays, software, CRO
laboratory, and lab equipment maintenance services (Benson, NC) for precision
measurement of physical chemical properties, including:
-Ionization Constant – pKa
-Lipophilicity - log P/log D
Founded in 1996 by Dr. Alex Avdeef,
Pion Inc. has been a leading innovator in the use of parallel artificial
membrane permeability assays (PAMPA), which determine the permeability of substances
from a donor compartment through a lipid-infused artificial membrane into an acceptor compartment.
Pion’s patented innovations in this area include Gastrointestinal, Blood Brain
Barrier, and Skin PAMPA models that offer drug developers a rugged, robust, and
affordable means of screening, promising drug compounds for passive membrane
Pion is perhaps best known for its
Rainbow fiber-optic monitoring system, which is used by all of the world’s top
20 pharmaceutical companies for comprehensive, high-frequency capture of in
situ UV dissolution data. The small-volume μDiss Profiler™ fiber-optic
system supports small-scale dissolution experiments that enable end users to obtain comprehensive data while saving
precious APIs and biorelevant media.
Recently, Pion has leveraged its
knowledge of PAMPA models and fiber optics to develop FLUX testing technology,
which combines traditional dissolution testing with a repeatable method for
assessing the absorption potential of APIs, API/ingredient combinations, or finished
dosage products. The result is a single combined test that makes more reliable and realistic
IVIVC (in vitro-in vivo correlation) testing and modeling possible.
Pion FLUX testing technology is available
in two sizes: MicroFLUX testing, offered as an option on the μDiss Profiler
system, is ideal for assessing early-stage APIs and unformulated combinations
in small-volume tests of 20 ml or less. MacroFLUX testing is used with the Rainbow
system and sized to evaluate the dissolution and absorption performance of
finished dosage products in volumes of 500ml, 900ml, or 1l.
Pion’s PULSE™ instrument offers a
cost-effective solution for pKa, log P/D, and solubility analysis. This
potentiometric system, which is powered by Pion Attain and Refine software,
offers both UV and autosampling options to meet a range of requirements and
The company’s latest offering, Field
Services, enables end users to outsource the maintenance, calibration, and
repair of all leading brands of laboratory equipment to skilled Pion personnel.
This record has been viewed 1359